RetrogeneDB–a database of plant and animal retrocopies
نویسندگان
چکیده
Database URL http://yeti.amu.edu.pl/retrogenedb. Secondary database URL http://rhesus.amu.edu.pl/retrogenedb.
منابع مشابه
RetrogeneDB—A Database of Animal Retrogenes
Retrocopies of protein-coding genes, reverse transcribed and inserted into the genome copies of mature RNA, have commonly been categorized as pseudogenes with no biological importance. However, recent studies showed that they play important role in the genomes evolution and shaping interspecies differences. Here, we present RetrogeneDB, a database of retrocopies in 62 animal genomes. RetrogeneD...
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In a broad range of taxa, genes can duplicate through an RNA intermediate in a process mediated by retrotransposons (retroposition). In mammals, L1 retrotransposons drive retroposition, but the elements responsible for retroposition in other animals have yet to be identified. Here, we examined young retrocopies from various animals that still retain the sequence features indicative of the under...
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MOTIVATION Retrocopies are copies of mature RNAs that are usually devoid of regulatory sequences and introns. They have routinely been classified as processed pseudo-genes with little or no biological relevance. However, recent findings have revealed functional roles for retrocopies, as well as their high frequency in some organisms, such as primates. Despite their increasing importance, there ...
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It is estimated that the human genome contains as many as 8 000–15 000 copies of protein coding genes generated by reverse transcription. Although majority of them are in the state of a “relaxed” selection and remain “dormant”, as they are lacking regulatory regions, many become functional. The evolutionary path of these functional retrogenes’ is not uniform. In the course of the evolution they...
متن کاملRetrogenes in Rice (Oryza sativa L. ssp. japonica) Exhibit Correlated Expression with Their Source Genes
Gene duplication occurs by either DNA- or RNA-based processes; the latter duplicates single genes via retroposition of messenger RNA. The expression of a retroposed gene copy (retrocopy) is expected to be uncorrelated with its source gene because upstream promoter regions are usually not part of the retroposition process. In contrast, DNA-based duplication often encompasses both the coding and ...
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عنوان ژورنال:
دوره 2017 شماره
صفحات -
تاریخ انتشار 2017